SUMO1 enhances cAMP-dependent exocytosis and glucagon secretion from pancreatic α-cells
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چکیده
منابع مشابه
Glucagon secretion from pancreatic α-cells
Type 2 diabetes involves a ménage à trois of impaired glucose regulation of pancreatic hormone release: in addition to impaired glucose-induced insulin secretion, the release of the hyperglycaemic hormone glucagon becomes dysregulated; these last-mentioned defects exacerbate the metabolic consequences of hypoinsulinaemia and are compounded further by hypersecretion of somatostatin (which inhibi...
متن کاملModel for Glucagon Secretion by Pancreatic α-Cells
Glucagon hormone is synthesized and released by pancreatic α-cells, one of the islet-cell types. This hormone, along with insulin, maintains blood glucose levels within the physiological range. Glucose stimulates glucagon release at low concentrations (hypoglycemia). However, the mechanisms involved in this secretion are still not completely clear. Here, using experimental calcium time series o...
متن کاملSomatostatin and insulin mediate glucose-inhibited glucagon secretion in the pancreatic α-cell by lowering cAMP.
The dysregulation of glucose-inhibited glucagon secretion from the pancreatic islet α-cell is a critical component of diabetes pathology and metabolic disease. We show a previously uncharacterized [Ca(2+)]i-independent mechanism of glucagon suppression in human and murine pancreatic islets whereby cAMP and PKA signaling are decreased. This decrease is driven by the combination of somatostatin, ...
متن کاملEphA4 Receptor Forward Signaling Inhibits Glucagon Secretion From α-Cells
The loss of inhibition of glucagon secretion exacerbates hyperglycemia in type 1 and 2 diabetes. However, the molecular mechanisms that regulate glucagon secretion in unaffected and diabetic states remain relatively unexplained. We present evidence supporting a new model of juxtacrine-mediated regulation of glucagon secretion where neighboring islet cells negatively regulate glucagon secretion ...
متن کاملGlucagon-like peptide-1 induces a cAMP-dependent increase of [Na ]i associated with insulin secretion in pancreatic -cells
Miura, Yoshikazu, and Hisao Matsui. Glucagon-like peptide-1 induces a cAMP-dependent increase of [Na ]i associated with insulin secretion in pancreatic islet -cells. Am J Physiol Endocrinol Metab 285: E1001–E1009, 2003; 10.1152/ajpendo.00005.2003.—Glucagon-like peptide-1 (GLP-1) elevates the intracellular free calcium concentration ([Ca2 ]i) and insulin secretion in a Na -dependent manner. To i...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 2014
ISSN: 0022-3751
DOI: 10.1113/jphysiol.2014.274084